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The Effect of Corticosteroids on Quality of Life Following Total Hip Arthroplasty: HIPSTER Study
Sponsor: Ziekenhuis Oost-Limburg
Summary
Total hip arthroplasty (THA) is a highly effective and commonly performed procedure for end-stage osteoarthritis. Perioperative inflammation contributes to postoperative pain, fatigue, and delayed recovery. Dexamethasone, a potent glucocorticoid with strong anti-inflammatory properties, is widely used in orthopedic surgery and incorporated into Enhanced Recovery After Surgery (ERAS) protocols for THA to reduce pain, PONV, and fatigue. While intermediate doses of dexamethasone (25 mg) are considered safe and beneficial in the short term, their long-term effects on health-related quality of life and persistent pain remain unclear. Therefore, the main objective of the HIPSTER trial is to evaluate the effect of different doses of a single intraoperative intravenous dose of dexamethasone (5 mg versus 25 mg) on health-related quality of life up to three months after surgery.
Key Details
Gender
All
Age Range
60 Years - Any
Study Type
INTERVENTIONAL
Enrollment
224
Start Date
2026-01-30
Completion Date
2027-02
Last Updated
2026-04-08
Healthy Volunteers
No
Interventions
Dexamethasone (IV)
Dexamethasone 5 mg IV
Dexamethasone (IV)
Dexamethasone 25 mg IV
Locations (2)
Ziekenhuis Oost-Limburg
Genk, Limburg, Belgium
Ziekenhuis Oost-Limburg
Genk, Belgium