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Effects of Selected Statins on Blood Glucose Levels in Healthy Volunteers
Sponsor: Shaheed Benazir Bhutto University Sheringal Dir Upper
Summary
This Phase I randomized clinical trial aims to investigate the short-term effects of three commonly prescribed statins (atorvastatin, rosuvastatin, and simvastatin) at different dose levels on blood glucose homeostasis in healthy volunteers. The study will assess changes in fasting blood glucose, insulin, and C-peptide levels following two days of statin administration under controlled conditions. The research seeks to provide comparative data on the potential diabetogenic effects of these medications.
Official title: Effects of Selected Statins on Blood Glucose Levels in Healthy Volunteers: A Randomized Phase I Clinical Trial
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2026-03-01
Completion Date
2027-02-20
Last Updated
2026-01-30
Healthy Volunteers
Yes
Conditions
Interventions
Simvastatin (10mg, 20mg, 40mg)
The Simvastatin (10mg, 20mg, 40mg) group participants will be given the drug orally OD for two days
Rosuvastatin (5mg, 20mg, 40mg)
The Rosuvastatin (5mg, 20mg, 40mg) group participants will be given the drug orally OD for two days
Atorvastatin (10mg, 20mg, 40mg)
The Atorvastatin (10mg, 20mg, 40mg) group participants will be given the drug orally OD for two days
Locations (2)
Shaheed Benazir Bhutto University Sheringal Dir Upper
Dīr, Khyber Pakhtunkhwa, Pakistan
Shaheed Benazir Bhutto University Sheringal Dir Upper
Dīr, Khyber Pakhtunkhwa, Pakistan