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ENROLLING BY INVITATION

NCT07378332

Towards Causal Mapping of Episodic Memory iEEG Networks Via Multi-method Brain Stimulation

Sponsor: University of Chicago

View on ClinicalTrials.gov

Summary

Human intracranial electroencephalography (EEG) can provide brain-activity correlates of memory with high spatial and temporal resolution. This project will test functional relevance of these neural signals for memory behavioral performance using novel noninvasive and invasive stimulation methods. Findings will advance understanding of brain mechanisms for memory, as is needed to accelerate progress in the treatment of memory disorders.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

Start Date

2025-09-15

Completion Date

2028-06-30

Last Updated

2026-01-30

Healthy Volunteers

Conditions

Memory Performance Hippocampal Activity

Interventions

OTHER

TMS electrical stimulation parameters during cognitive and memory demands

Study conditions will involve electrical stimulation delivered through non-invasive TMS. These different stimulation parameters will include the presence of stimulation (no stimulation versus stimulation) and the location of stimulation.

OTHER

DES electrical stimulation parameters during cognitive and memory demands

Study conditions will involve direct electrical stimulation delivered through implanted iEEG electrodes. These different stimulation parameters will include the presence of stimulation (no stimulation versus stimulation) and the location of stimulation across the same electrode or a different electrode.

Locations (3)

Northwestern Memorial Hospital

Chicago, Illinois, United States

University of Chicago Medical Center