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Comparison of Nebulized Ketamine With Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat
Sponsor: Sohag University
Summary
The aim of this study is to compare the efficacy of nebulized ketamine versus nebulized magnesium sulfate in reducing the incidence and severity of POST. * Primary outcome • To compare the incidence of POST method. * Secondary outcomes * Onset, Severity, and duration of POST at 0, 2, 4, 6, 12, 24 hours postoperative. * The hemodynamics recording (HR, BP, MBP, pre and post nebulization) * Adverse Effects (e.g., sedation, cough, nausea, vomiting, ….)
Official title: Comparison of Nebulized Ketamine With Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat in Adult Surgical Patients Undergoing General Anesthesia: Prospective Randomized Controlled Study
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2026-02-01
Completion Date
2026-09-01
Last Updated
2026-02-03
Healthy Volunteers
Yes
Conditions
Interventions
Ketamine nebulizer
50 patients will receive preoperative nebulization with 50 mg ketamine in 5 ml normal saline.
Mg sulfate nebulizer
50 patients will receive preoperative nebulization with 250 mg magnesium sulfate in 5 ml normal saline.
Placebo
50 patients will receive preoperative nebulization with 5 ml normal saline.