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RECRUITING

NCT07381127

INTUPRO in the Treatment of Benign Prostatic Hyperplasia-Related Symptoms

Sponsor: inTumo Therapeutics, Inc.

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to determine whether INTUPRO can improve the quality of life in patients with Benign Prostate Hyperplasia (BPH). The main questions it aims to answer are: Can INTUPRO treatment lead to the removal of the Foley catheter? Can INTUPRO treatment improve urinary flow? Can INTUPRO treatment lower or minimize waking during sleep to urinate? Can INTUPRO reduce urinary hesitancy, urgency and frequency? Participants will: Receive INTUPRO treatment on Day 1. Visit at Day 30 and Day 90 for checkups, tests and Prostate MRI.

Official title: A Study to Evaluate the Safety and Efficacy of Ionic Fluid in Treating Symptoms in Patients With Benign Prostatic Hyperplasia. A Prospective, Single-arm, Single-center Clinical Study.

Key Details

Gender

MALE

Age Range

45 Years - Any

Study Type

INTERVENTIONAL

Enrollment

Start Date

2025-03-04

Completion Date

2027-12

Last Updated

2026-02-02

Healthy Volunteers

Conditions

BPH (Benign Prostatic Hyperplasia)BPH BPH With Other Lower Urinary Tract Symptoms

Interventions

DEVICE

INTUPRO ionic fluid

Under TRUS imaging, a fixed dose of the ablative agent will be administered to patients by the physician via needle. Each patient will receive a total of 4-10 mL ionic fluid , administered as two separate 2-5 mL injections into each side of the prostatic urethra.

Inclusion Criteria: * • Male patient aged 45 years or older * Prostate volume greater than 30 grams * An International Prostate Symptom Score (IPSS) of 12 or higher * Presence of obstructive urinary symptoms, such as difficulty starting urination, leakage of urine after voiding, or a feeling of incomplete bladder emptying. This criterion may include patients who have previously been diagnosed with prostate cancer and completed treatment, but are experiencing urinary problems. * Life expectancy of at least 3 months * Ability to understand the study information and provide written informed consent * Willingness and ability to comply with all study requirements, including procedures, clinical assessments, and follow-up visits Exclusion Criteria: * Urethral stricture * Bladder stones * Prostate volume 120 grams or greater * Presence of a prostate median lobe * History of bladder cancer or kidney cancer, and/or prior surgery related to these conditions * Previous radiation therapy to the pelvic region * Prior invasive surgical treatment for BPH symptoms * The Principal Investigator believes the patient would not tolerate the procedure * Presence of a cognitive impairment that, in the opinion of the Principal Investigator, would interfere with the patient's ability to provide reliable data or to safely complete the study * Bleeding disorders * Known allergy or intolerance to MRI contrast agents required for imaging used to evaluate treatment effectiveness after ionic fluid application * Other significant concurrent medical conditions that, in the investigator's judgment, could prevent clinical benefit from the procedure or could place the patient or study objectives at risk (including, but not limited to, active infection, kidney dysfunction, or significant comorbidities) * Significant medical or psychiatric illness * Participation in another clinical study involving a device, drug, or procedure that has not been completed or that could affect the outcomes of this study * Inability or unwillingness to undergo MRI examinations during the study period for any reason

Locations (1)

Koç University Hospital Research Center

Istanbul, Turkey (Türkiye)