Clinical Research Directory

Inclusion Criteria: * Inclusion Criteria 1. Adult male or female, age ≥18 2. Undergoing allogeneic SCT at UAB for any indication and any donor source. 3. For patients in cohort 1: Patients deemed high-risk for developing high-risk TA-TMA as stated by any of the following criteria\*: 1. BMI \> 35\[42\] 2. Mismatched donor (either Haploidentical or Mismatched Unrelated donor)\[18, 29\] 3. Non-Malignant Transplant Indication (Severe Aplastic Anemia or Sickle Cell Disease)\[18, 43\] 4. Acute Lymphoblastic Leukemia (any kind)\[18, 31\] 5. African American, Hispanic, Asian or Native American Ethnicity \[44\] 6. Myeloablative Conditioning Regimen\[18\] 7. Pre-Existing Renal Disease\*\* (defined as any of the following: 24 Hr Creatinine Clearance \<60, baseline serum creatinine \> 1.2, 24 hr proteinuria \>150mg or random spot urine Protein Creatinine ratio \> 150mg/g)\[20, 45\] 8. TBI-containing conditioning regimen \>400cGy \[46\] 9. Prior Autologous or Allogeneic SCT\[45\] * \*Some of these criteria have been adapted from pediatric literature due to a higher number of publications in that setting and in cases where the adult data is lacking or contradictory. * \*\*Proteinuria thresholds are obtained from KDIGO guidelines and include moderate and severe levels of proteinuria\[47\]. 4. Females of childbearing potential must have a negative urine or serum pregnancy test prior to enrollment. 5. For patients in cohort 2: Patients who develop GVHD with any of the following characteristics and were not included in cohort 1 1. Grade III-IV aGVHD, or SR-aGVHD of any grade, whichever occurs first 2. Moderate to Severe cGVHD or SR-cGVHD of any grade, whichever occurs first 6. For patients in cohort 3: Patients included in either cohort 1 or 2 who are diagnosed with TA-TMA and receive eculizumab Exclusion Criteria: * Exclusion Criteria 1. Any other active malignancy requiring treatment or with expected survival ≤1 year. 2. Patients with psychiatric illness or social situations that would limit compliance with the study requirements.