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RECRUITING
NCT07381920
NA

Effects of Muscle Cooling on Motor Unit Firing of the Quadriceps

Sponsor: Wake Forest University

View on ClinicalTrials.gov

Summary

The overall objective of this pilot study is to establish the feasibility and methodological validity of using high-density surface electromyography to characterize motor unit behavior of the quadriceps under thermoneutral and locally cooled conditions, and to generate preliminary data to inform the design of a larger, hypothesis-driven study.

Official title: Effects of Muscle Cooling on Motor Unit Firing of the Quadriceps: A Pilot Feasibility Study

Key Details

Gender

All

Age Range

18 Years - 35 Years

Study Type

INTERVENTIONAL

Enrollment

24

Start Date

2026-01-20

Completion Date

2027-05

Last Updated

2026-02-27

Healthy Volunteers

Yes

Conditions

Interventions

PROCEDURE

Cryotherapy

For the cold condition, an Aircast Thigh Pad (Aircast), connected to the Cryo Cuff IC cooler (DJO Global, Vista, California, USA) will be applied to the dominant thigh. The system circulates ice water maintained at approximately 10-15°C with intermittent compression. Cooling duration will be individualized based on mid-thigh skinfold thickness, consistent with published recommendations that account for the effect of subcutaneous tissue on intramuscular cooling9. Participants with a mid-thigh skinfold thickness of 0-10 mm will receive 10 minutes of cooling; those with a skinfold thickness of 11-20 mm will receive 25 minutes of cooling; those with a skinfold thickness of 21-30 mm will receive 40 minutes of cooling; and those with a skinfold thickness of 31-40 mm will receive 60 minutes of cooling. Participants will remain seated for the duration of the cooling treatment.

Locations (1)

Department of Health and Exercise Science at Wake Forest University

Winston-Salem, North Carolina, United States