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Preventing Neurologic Complications in Valve Surgery
Sponsor: China National Center for Cardiovascular Diseases
Summary
In patients with valvular heart disease and atrial fibrillation (AF) undergoing surgical valve surgery, current guidelines recommend concomitant surgical management of the left atrial appendage (LAA) to prevent postoperative thromboembolic events, particularly neurologic embolic events. However, whether concomitant LAA management benefits patients without AF by reducing postoperative neurologic complications remains controversial. Given these uncertainties, this study aims to evaluate whether concomitant LAA suture closure during surgical valve surgery is associated with a lower incidence of perioperative silent cerebral infarction.
Official title: Strategies for the Prevention of Perioperative Neurological Complications in Cardiac Valve Surgery
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2026-01-27
Completion Date
2028-07-31
Last Updated
2026-02-02
Healthy Volunteers
No
Conditions
Interventions
Left Atrial Appendage (LAA) Suture Closure
Concomitant suture closure of the LAA performed at the time of surgical valve surgery, at the discretion of the operating surgeon.
Surgical Valve Surgery
Standard surgical valve repair or replacement performed according to routine clinical practice.
Locations (4)
Fuwai Hospital Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China
Peking University First Hospita
Beijing, Beijing Municipality, China
Qingdao Cardiovascular Hospital
Qingdao, China
Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen
Shenzhen, China