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NeoAdjuvant ChemoTherapy With KELIM Guided Interval vs. Delayed Interval Debulking Surgery
Sponsor: Aristotle University Of Thessaloniki
Summary
A prospective, international, multi-center, interventional trial of advanced epithelial ovarian cancer patients offered three cycles of neoadjuvant chemotherapy (NACT) and triaged with KELIM score. Patients with favorable score will undergo interval debulking surgery (IDS) followed by another 3 cycles, while those with unfavorable score will undergo another 3 cycles of NACT followed by delayed interval debulking surgery (DIDS).
Official title: A Prospective, International, Multi-center, Interventional Trial of Advanced Epithelial Ovarian Cancer Patients Offered Three Cycles of Neoadjuvant Chemotherapy (NACT) and Triaged With KELIM Score. Patients With Favorable Score Will Undergo Interval Debulking Surgery (IDS) Followed by Another 3 Cycles of NACT, While Those With Unfavorable Will Undergo Another 3 Cycles of NACT Followed by Delayed Interval Debulking Surgery (DIDS).
Key Details
Gender
FEMALE
Age Range
18 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
485
Start Date
2026-04-01
Completion Date
2034-04-01
Last Updated
2026-02-05
Healthy Volunteers
No
Conditions
Interventions
3 cycles of NACT with unfavorable KELIM score will receive 3 more cycles of NACT followed by DIDS
3 cycles of NACT with unfavorable KELIM score will receive 3 more cycles of NACT followed by DIDS
3 cycles of NACT with favorable KELIM score will undergo IDS followed by 3 cycles of NACT
3 cycles of NACT with favorable KELIM score will undergo IDS followed by 3 cycles of NACT