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Assessment of GARP Expression in Acute and Chronic Coronary Syndrome
Sponsor: Université Catholique de Louvain
Summary
The leading cause of death is cardiovascular diseases in occidental countries. Of those, atherosclerosis is the major contributor to this burden being notably responsible for strokes and myocardial infarctions. The genesis of atherosclerosis is linked to both lipid accumulation and inflammation in the vascular wall of major arteries. One of the major pathways of inflammation is the TGF-beta axis which is at least partially regulated by the GARP protein. It has been investigated mostly in cancer biology but data in cardiovascular disease is lacking. Thus, the investigators aim to characterize the contribution of this protein by investigating its expression in circulating blood cells from patients with an acute or chronic coronary syndrom. The main cells expressing the GARP protein are the platelets and the T regulating cells which will be the main focus.
Official title: Assessment of GARP Expression and Inflammatory Cytokines in Acute and Chronic Coronary Syndrome
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
600
Start Date
2026-02
Completion Date
2028-01
Last Updated
2026-02-17
Healthy Volunteers
No
Conditions
Interventions
Arterial blood sample
An arterial blood sample will be obtained at the beginning of the coronary angiography by using the arterial sheat in place.
Locations (1)
Cliniques Universitaires Saint-Luc
Brussels, Belgium