Clinical Research Directory

Inclusion Criteria: * Healthy woman, aged of 45 to 65 years (inclusive) * In postmenopause, defined according to the STRAW criteria as the absence of menstrual periods for at least 12 consecutive months * Reporting a vaginal dryness intensity score ≥ 4 on a 0-10 Visual Analogue Scale (VAS), and a score ≥ 16 on the Menopause Rating Scale (MRS) * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * Stated willingness to maintain their usual life habits (diet, physical activity, alcohol consumption…) * Speaking French. Exclusion Criteria: * Use of systemic hormonal therapy within the past 3 months * Use of dietary supplements, herbal products, or over-the-counter remedies intended to alleviate menopausal symptoms within 4 weeks prior to the screening visit (wash-out period ≥ 1 month required) * Use of vaginal hormonal formulations within 4 weeks prior to screening * History of hormone-dependent cancers * History of hysterectomy or bilateral oophorectomy * Current alcohol dependence or excessive alcohol consumption exceeding an average of 14 standard drinks per week * Current use of illicit drugs or recent history of drug dependence * Current or previously diagnosed eating disorders considered likely to impact participant safety or study outcomes * Presence of severe or uncontrolled chronic medical conditions, or any acute medical condition judged by the investigator to potentially interfere with the MRS assessment or participant safety * Subject participating in another intervention trial