Clinical Research Directory

Inclusion Criteria: * Men ≥18 years of age * Serum Prostate-specific antigen (PSA) 4-15 ng/mL, repeated at least once * Prostate mpMRI done within 6 months * MRI prostate with PI-RADS (11) scores of: * PI-RADS score 2 with red flag (PSA density \>0.2 OR Prostate health index, PHI\>35), * PI-RADS 3, OR * PI-RADS 4 with lower csPCa risks (PSAd \<0.1 OR PHI\<35) * Normal Digital rectal examination * Patient agrees for targeted and systematic prostate biopsy Exclusion Criteria: * Prostate biopsy within past 5 years * Past or current history of prostate cancer * Contraindicated to undergo PSMA PET-CT scan * Contraindicated to prostate biopsy: active urinary tract infection, fail insertion of transrectal ultrasound probe into rectum (abdominal perineal resection, anal stenosis), fail to be placed in lithotomy position, uncorrectable coagulopathy, antiplatelet or anticoagulant which cannot be stopped (keep aspirin before and after biopsy is permitted)