Clinical Research Directory

Inclusion Criteria: 1. Prospective enrollment of otolaryngology clinic patients aged 18-65 years with olfactory dysfunction. Diagnosis of post-infectious olfactory dysfunction (PIOD) will be based on the PPOD 2023 criteria. Participants must demonstrate olfactory impairment via Sniffin' Sticks testing, with TDI scores (sum of Threshold, Discrimination, and Identification) meeting: (1) Hyposmia: 16 \< TDI \< 30.75; (2) Anosmia: TDI ≤ 15. 2. Willingness to participate and signed informed consent. Exclusion Criteria: 1. Use of systemic corticosteroids within 4 weeks or intranasal steroids within 2 weeks prior to enrollment. 2. Severe nasal septum deviation, nasal tumors, acute upper respiratory infections, or uncontrolled allergic rhinitis. 3. History of functional endoscopic sinus surgery or other nasal procedures within 12 months. 4. Severe cardiovascular disease, hepatic/renal insufficiency, uncontrolled diabetes, or immune system disorders. 5. Current or planned pregnancy. 6. Investigator-determined inability to comply with study requirements (e.g., memory/behavioral disorders, depression, heavy alcohol use, prior non-compliance).