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A Clinical Study of MK-4082 in Healthy Overweight Participants (MK-4082-002)
Sponsor: Merck Sharp & Dohme LLC
Summary
Researchers are looking for new weight loss medicines for people with higher body weight. The study medicine, MK-4082, is different from similar weight loss medicines because people take it as a pill instead of an injection. Before giving a study medicine to people with a health condition, researchers first do studies to find a safe dose level (amount) of the study medicine that can be used in future studies. The goals of this study are to learn about: * The safety of MK-4082 and if people tolerate it * What happens to different MK-4082 dose levels in a person's body over time
Official title: A Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of MK-4082 in Healthy Overweight/Obese Participants
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2026-03-04
Completion Date
2026-08-19
Last Updated
2026-03-30
Healthy Volunteers
Yes
Conditions
Interventions
MK-4082
Oral Tablet
Placebo
Oral Tablet
Locations (5)
Anaheim Clinical Trials ( Site 0005)
Anaheim, California, United States
ProSciento Inc. ( Site 0002)
Chula Vista, California, United States
QPS-MRA, LLC ( Site 0003)
South Miami, Florida, United States
Bio-Kinetic Clinical Applications, LLD dba QPS-MO ( Site 0004)
Springfield, Missouri, United States
Hassman Research Institute Marlton Site ( Site 0006)
Marlton, New Jersey, United States