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[Effects of Selected Statins on Cardiovascular Parameters in Healthy Volunteers]
Sponsor: Shaheed Benazir Bhutto University Sheringal Dir Upper
Summary
This study is a Phase I randomized clinical trial aiming to investigate the short-term effects of three commonly prescribed statins i.e (Atorvastatin, Rosuvastatin, and Simvastatin) at different dose levels i.e lo,median and high doses on cardiovascular parameters i.e Blood pressure and ECG morphology in healthy volunteers. The study will assess changes in blood pressure and ECG morphology following two days of statin administration under controlled conditions.
Official title: [EFFECTS OF SELECTED STATINS ON CARDIOVASCULAR PARAMETERS IN HEALTHY VOLUNTEERS: A RANDAMOZIED PHASE I CLINICAL TRIAL]
Key Details
Gender
All
Age Range
18 Years - 25 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2026-03-01
Completion Date
2027-02-20
Last Updated
2026-02-05
Healthy Volunteers
Yes
Conditions
Interventions
Rosuvastatin (5mg, 20mg, 40mg)
The Rosuvastatin (5mg, 20mg, 40mg) group participants will be given the drug orally OD for two days
Atorvastatin (10mg, 20mg, 40mg)
The Atorvastatin (10mg, 20mg, 40mg) group participants will be given the drug orally OD for two days
Simvastatin (10mg, 20mg, 40m
The Simvastatin (10mg, 20mg, 40mg) group participants will be given the drug orally OD for two days
Locations (1)
Shaheed Benazir Bhutto University Sheringal Dir Upper
Dīr, Khyber Pakhtunkhwa, Pakistan