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A Study of HRS-6208 in Combination With HRS-8080, or Fulvestrant, or Letrozole, With or Without HRS-6209 in Patients With Advanced Unresectable or Metastatic Breast Cancer
Sponsor: Shandong Suncadia Medicine Co., Ltd.
Summary
This study aims to evaluate the safety, tolerability, efficacy and pharmacokinetics of HRS-6208 in combination with HRS-8080 ± HRS-6209, or in combination with fulvestrant ± HRS-6209, or in combination with letrozole ± HRS-6209 in patients with advanced unresectable or metastatic breast cancer.
Official title: Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HRS-6208 in Combination With HRS-8080 ± HRS-6209, or in Combination With Fulvestrant ± HRS-6209, or in Combination With Letrozole ± HRS-6209 in Patients With Advanced Unresectable or Metastatic Breast Cancer: an Open Label, Multicenter, Phase Ib/II Study
Key Details
Gender
FEMALE
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
180
Start Date
2026-03-27
Completion Date
2028-12
Last Updated
2026-04-03
Healthy Volunteers
No
Interventions
HRS-6208 Capsule
HRS-6208 capsule.
HRS-6209 Capsule
HRS-6209 capsule.
HRS-8080 Tablet
HRS-8080 tablet.
Fulvestrant injection
Fulvestrant injection.
Letrozole tablets
Letrozole tablets.
Locations (2)
The Second Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, China
West China Hospital, Sichuan University
Chengdu, Sichuan, China