Clinical Research Directory

Inclusion Criteria: * Inclusion criteria for the study: 1. Patients aged 18-50 years 2. Patients with ASA I status 3. Patients with Type 2 diabetes whose HbA1c values are between 5.5% and 9.0%, with diabetes diagnosis confirmed by medical history and laboratory tests (HbA1c test) 4. Upper and lower incisors and lower premolars with chronic apical periodontitis, 5. Teeth requiring retreatment with a PAI score ≥3 will be included in the study. (15) Exclusion criteria: 1. ASA II or higher, 2. Pregnant women or those suspected of being pregnant, 3. Patients with localized or generalized periodontitis, 4. Patients with inflammatory or autoimmune diseases such as hepatitis, HIV infection, immunosuppressive chemotherapy, bleeding disorders, Behçet's syndrome, and arthritis, 5. Individuals with HbA1c levels above 9%, 5\. Those who have used antibiotics within the last month and anti-inflammatory drugs within the last week, 6. Smokers, 7. Patients with periodontal pockets greater than 3 mm in the relevant tooth, 8. Those with internal or external root resorption, 9. Those with swelling, palpation pain, or a fistula in the relevant area, 10. Those with root fracture or incomplete root formation, 11. Teeth that cannot be isolated with a rubber dam will not be included in the study. The name, surname, age, gender, contact information, and tooth number to be treated of patients included in the study will be recorded on the case report form. Periapical radiographs will be taken of the relevant teeth prior to root canal treatment to examine the root canal anatomy. The periapical health status of each tooth will be assessed using the PAI score.