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RECRUITING
NCT07390864
NA

Ergometrine Versus Carbetocin to Decrease Blood Loss in Myomectomy

Sponsor: Cairo University

View on ClinicalTrials.gov

Summary

The goal of this randomized clinical trial is to determine whether intramyometrial ergometrine injection or intramyometrial carbetocin injection is more effective in reducing blood loss during and after abdominal myomectomy in women undergoing surgery for symptomatic uterine fibroids. The main questions it aims to answer are: Does intramyometrial ergometrine reduce intraoperative and postoperative blood loss during abdominal myomectomy? Does intramyometrial carbetocin reduce intraoperative and postoperative blood loss during abdominal myomectomy? Is there a difference between the two drugs in the need for blood transfusion and postoperative hemoglobin drop? Researchers will compare intramyometrial ergometrine injection with intramyometrial carbetocin injection to see which intervention is more effective in controlling surgical bleeding and improving surgical outcomes. Participants will: Undergo abdominal myomectomy for uterine fibroids Receive either intramyometrial ergometrine or intramyometrial carbetocin during surgery Be monitored for intraoperative blood loss, postoperative blood loss, hemoglobin changes, and need for blood transfusion

Official title: Intramyometrial Ergometrine Injection Versus Intramyometrial Carbetocin Injection to Decrease Blood Loss During and After Abdominal Myomectomy: A Randomized Clinical Trial

Key Details

Gender

FEMALE

Age Range

25 Years - 48 Years

Study Type

INTERVENTIONAL

Enrollment

40

Start Date

2026-01-18

Completion Date

2026-08-30

Last Updated

2026-02-05

Healthy Volunteers

No

Conditions

Interventions

DRUG

Methylergometrine (Intramyometrial Injection)

Methylergometrine maleate is administered as an intramyometrial injection diluted in normal saline and injected circumferentially around the myoma before uterine incision during abdominal myomectomy to induce sustained uterine contraction and reduce surgical blood loss.

DRUG

Carbetocin (Intramyometrial Injection)

Carbetocin is administered as an intramyometrial injection diluted in normal saline and injected circumferentially around the myoma before uterine incision during abdominal myomectomy to promote sustained uterine contraction and reduce intraoperative and postoperative blood loss.

Locations (1)

Fayoum University

Al Fayyum, Faiyum Governorate, Egypt