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GLS in Difficult CPB Weaning
Sponsor: Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Summary
The goal of this observational study is to learn whether global longitudinal strain (GLS), measured by echocardiography, can predict difficulty separating from cardiopulmonary bypass (CPB) in adults undergoing elective cardiac surgery. The main questions it aims to answer are: * Can preoperative GLS measurement predict difficult separation from CPB? * Are GLS values associated with outcomes such as intensive care unit (ICU) stay, hospital stay, cardiac biomarkers, or 30-day mortality? Participants will: * Undergo standard cardiac surgery requiring CPB * Have echocardiographic assessments (TTE before and after surgery) * Have their recovery and outcomes monitored, including ICU and hospital stay, postoperative labs, and survival within 30 days
Official title: Global Longitudinal Strain as a Predictor of Difficult Separating From Cardiopulmonary Bypass
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
213
Start Date
2026-02-05
Completion Date
2026-08-30
Last Updated
2026-02-05
Healthy Volunteers
No
Conditions
Interventions
Myocardial strain imaging
Two-dimensional strain analysis was performed using frame-by-frame tracking of unique patterns of bright and dark pixels in grayscale (B-mode) sector images to assess myocardial deformation. The frame rate was maintained between 40 and 90 Hz. The myocardium in each image was divided into six myocardial segments, which were individually assessed for tracking quality. GLS was calculated as the average strain value of 18 myocardial segments obtained from the three echocardiographic views. Patients were included in the final analysis if at least 15 out of 18 segments were considered acceptable for strain measurement by the investigator.
Locations (2)
University of Rome Tor Vergata
Rome, Italy
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Istanbul, Turkey (Türkiye)