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Peripheral Perfusion and Outcomes in ICU Patients With Sepsis
Sponsor: Alexandra Elena Lazăr
Summary
People with sepsis who are treated in the intensive care unit (ICU) often have impaired blood flow to the skin and other tissues. These alterations in tissue perfusion may be associated with disease severity and clinical outcomes. The aim of this study is to see whether simple signs of blood flow to the skin, such as capillary refill time and blood test measurements, are linked to outcomes in people with sepsis treated in the ICU. Adults with sepsis who are admitted to the ICU will be invited to take part. Researchers will collect routine clinical data and blood test results during the first day of ICU treatment. No extra procedures or treatments will be performed as part of the study. The results of this study may improve understanding of early signs of impaired circulation in sepsis and their relation with recovery and survival.
Official title: Peripheral Perfusion and Outcomes in ICU Patients With Sepsis (PERFUSE-ICU)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
80
Start Date
2026-02-02
Completion Date
2026-09-30
Last Updated
2026-02-09
Healthy Volunteers
No
Conditions
Interventions
PERIPHERAL PERFUSION EVALUATION
This intervention consists of a predefined, multimodal peripheral perfusion assessment combining bedside clinical evaluation and blood gas analysis. Capillary refill time is measured at standardized time points, together with concurrent end-tidal carbon dioxide recording. Paired arterial and venous blood gas samples are obtained at the same time points to calculate the veno-arterial carbon dioxide difference and assess lactate levels. The intervention is limited to repeated physiological measurements during the first 24 hours of ICU admission and does not include any therapeutic intervention or protocol-driven change in clinical management
Locations (1)
Emergebcy Clinical County Hospital - Intensive Care Clinic
Târgu Mureş, Mureș County, Romania