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ACTIVE NOT RECRUITING
NCT07391696
NA

Coffee Intake Biomarker Validation and Association With Respiratory Diseases

Sponsor: National University of Singapore

View on ClinicalTrials.gov

Summary

This proposed project aims to identify and validate biomarkers of coffee exposure in the Singapore population, and assess the association between coffee consumption (via biomarker measurements) and risk of respiratory diseases in a prospective multi-ethnic cohort in Singapore. Specific Aim 1: To identify and quantify urinary/serum metabolite changes that are associated with coffee consumption in a dose-response intervention study.

Key Details

Gender

All

Age Range

21 Years - 64 Years

Study Type

INTERVENTIONAL

Enrollment

100

Start Date

2020-10-01

Completion Date

2026-12-31

Last Updated

2026-02-06

Healthy Volunteers

Yes

Conditions

Interventions

DIETARY_SUPPLEMENT

Coffee A

Week 1: coffee A ≤10 g coffee powder for low dose Week 2: non-coffee consumption (post-consumption kinetics) Week 3: coffee A ≤20 g coffee powder for medium dose Week 4: non-coffee consumption (post-consumption kinetics) Week 5: coffee A ≤40 g coffee powder for high dose Week 6: non-coffee consumption (post-consumption kinetics)

DIETARY_SUPPLEMENT

Coffee B

Week 7: coffee B ≤40 g coffee powder for high dose Week 8: non-coffee consumption (post-consumption kinetics)

DIETARY_SUPPLEMENT

Tea

Week 9: washout Week 10: tea (control) Week 11: non-coffee consumption (post-consumption kinetics)

Locations (1)

Saw Swee Hock School of Public Health, National University of Singapore

Singapore, Singapore, Singapore