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Coffee Intake Biomarker Validation and Association With Respiratory Diseases
Sponsor: National University of Singapore
Summary
This proposed project aims to identify and validate biomarkers of coffee exposure in the Singapore population, and assess the association between coffee consumption (via biomarker measurements) and risk of respiratory diseases in a prospective multi-ethnic cohort in Singapore. Specific Aim 1: To identify and quantify urinary/serum metabolite changes that are associated with coffee consumption in a dose-response intervention study.
Key Details
Gender
All
Age Range
21 Years - 64 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2020-10-01
Completion Date
2026-12-31
Last Updated
2026-02-06
Healthy Volunteers
Yes
Conditions
Interventions
Coffee A
Week 1: coffee A ≤10 g coffee powder for low dose Week 2: non-coffee consumption (post-consumption kinetics) Week 3: coffee A ≤20 g coffee powder for medium dose Week 4: non-coffee consumption (post-consumption kinetics) Week 5: coffee A ≤40 g coffee powder for high dose Week 6: non-coffee consumption (post-consumption kinetics)
Coffee B
Week 7: coffee B ≤40 g coffee powder for high dose Week 8: non-coffee consumption (post-consumption kinetics)
Tea
Week 9: washout Week 10: tea (control) Week 11: non-coffee consumption (post-consumption kinetics)
Locations (1)
Saw Swee Hock School of Public Health, National University of Singapore
Singapore, Singapore, Singapore