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Understanding the Role of the Locus Coeruleus in Insomnia
Sponsor: Woolcock Institute of Medical Research
Summary
This research project aims to better understand the neurobiological mechanistic underpinnings of insomnia disorder. The main question is whether cortical hyperarousal in individuals with insomnia disorder, measured by electroencephalograhic (EEG) infraslow oscillation coupling of sigma power during non-rapid eye movement (NREM) sleep and theta power during rapid eye movement (REM) sleep, is related to locus coeruleus activity.
Official title: An Alpha2-adrenoceptor Agonist to Reduce Locus Coeruleus Activity During Sleep in Adults With Insomnia Disorder: a Pilot Randomised Placebo-controlled Cross-over Study
Key Details
Gender
All
Age Range
30 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2026-02
Completion Date
2027-03
Last Updated
2026-02-06
Healthy Volunteers
No
Conditions
Interventions
Dexmedetomidine
A buccal tablet containing 96 µg dexmedetomidine will be taken before habitual bedtime.
Placebo
Placebo tablets will contain identical excipient without the active ingredient (dexmedetomidine) and manufactured under the same condition as the active. Placebo tablets, packs and instructions will be identical in every respect to enable the double-blind study design.
Locations (1)
Woolcock Institute of Medical Research
Macquarie Park, New South Wales, Australia