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Effect of Ipratropium Bromide on EILO
Sponsor: Cook Children's Health Care System
Summary
The investigators propose a study that compares breathlessness and airway obstruction during intense exercise in 34 children and adolescents with Exercise-Induced Laryngeal Obstruction after breathing in ipratropium bromide or placebo. It is hypothesized that breathlessness and airway obstruction will be lower following breathing in ipratropium bromide compared with placebo.
Official title: The Effect of Ipratropium Bromide on Exercise-Induced Laryngeal Obstruction (EILO) in Pediatric Patients
Key Details
Gender
All
Age Range
8 Years - 17 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2026-03-16
Completion Date
2029-03-30
Last Updated
2026-02-06
Healthy Volunteers
No
Interventions
Ipratropium Bromide
Nebulized Ipratropium Bromide (500µg/2.5mL); one-time dose approximately 75 minutes before exercise, inhaled for 5-8 minutes
Normal Saline (Placebo)
3 mL of nebulized 0.9% normal saline; one-time dose approximately 75 minutes before exercise, inhaled for 5-8 minutes
Locations (1)
Cook Children's Pulmonology (Exercise Respiratory Center)
Prosper, Texas, United States