Clinical Research Directory

Inclusion Criteria: * Subjects are diagnosed with primary insomnia between 18 and 60 years old，gender is not limited. * Patients who are not taking sedative-hypnotic drugs or have stopped taking drugs for more than 2 weeks. * Residing in the plains all year round and not having been above 1500 meters above sea level in the past 30 days. * Quiet state SaO2 ≥ 90%, cerebral oxygen saturation 58-82%, heart rate 60-100 beats/min, blood pressure 90-140/60-90 mmHg, respiratory rate 16-20 times/min. * No functional drinks, caffeine-containing beverages, or sleep-disturbing medications during the study period. Exclusion Criteria: * Stroke onset in the past 3 months, other severe neurological diseases, such as epilepsy, intracranial infectious diseases or demyelination. * Uncontrolled hypertension (systolic blood pressure ≥200mmHg) with antihypertensive drugs before enrollment, other cardiovascular diseases. * History of pulmonary, hepatic, dermatologic, or hematologic diseases. * History of substance abuse. * Pregnancy, Severe sleep apnea and neurological disorders.