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Using Different Biomaterials to Preserve Bone After Tooth Extraction
Sponsor: Inonu University
Summary
This clinical study aims to evaluate the effectiveness of different biomaterials in alveolar socket preservation following tooth extraction. Participants will be allocated into three groups: (1) dentin graft, (2) dentin graft combined with hyaluronic acid, (3) allograft and (4) natural healing without any grafting material (control group). At 4 months post-extraction, dental implants will be placed, and bone biopsies will be obtained during the procedure. These biopsy samples will be subjected to histological analysis to assess new bone formation and graft integration. The study will contribute to the understanding of biomaterial performance in socket preservation prior to implant placement.
Official title: Evaluating the Effectiveness of Various Biomaterials for Alveolar Socket Preservation
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-04-09
Completion Date
2026-06
Last Updated
2026-03-27
Healthy Volunteers
No
Interventions
Allograft
Following tooth extraction, the socket is filled with particulate freeze-dried allograft. The material is placed in a single session immediately after extraction to support socket preservation. Healing is monitored clinically at scheduled follow-up visits.
Autogenous Dentin Graft
After tooth extraction, autogenous dentin is processed into particulate graft form and placed into the socket in the same session. The graft is used for socket preservation, and healing is assessed clinically during planned follow-up visits.
Hyaluronic Acid Gel
A hyaluronic acid gel is applied as an adjunct biomaterial in combination with dentin graft material during socket preservation. Tissue response is evaluated at scheduled follow-up visits.
Locations (1)
Inonu University Faculty of Dentistry
Malatya, Battalgazi-Malatya, Turkey (Türkiye)