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A Platform Study of In Vivo CAR-T for Treating Advanced Malignant Tumors Based on Target Screening
Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Summary
This is a single-arm, open-label, single-center, dose-escalation Phase I platform study designed to evaluate the safety, tolerability, preliminary efficacy, pharmacokinetics, and pharmacodynamics of an in vivo CAR-T therapy (V001 Injection, targeting BCMA, GPRC5D, DLL3, etc.) in patients with advanced malignant tumors.
Official title: A Phase I Study of the In Vivo CAR-T Platform for Treating Advanced Malignant Tumors Based on Target Screening
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2025-11-21
Completion Date
2027-12
Last Updated
2026-02-09
Healthy Volunteers
No
Conditions
Interventions
V001-BCMA
An in vivo CAR-T drug targeting BCMA administered intravenously
V001-GPRC5D
An in vivo CAR-T drug targeting GPRC5D administered intravenously
V001-DLL3
An in vivo CAR-T drug targeting DLL3 administered intravenously
Locations (1)
Cancer Hospital Chinese Academy of Medical Sciences 17 Panjiayuan Nanli, Chaoyang District
Beijing, Beijing Municipality, China