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RECRUITING
NCT07395479
EARLY_PHASE1

A Platform Study of In Vivo CAR-T for Treating Advanced Malignant Tumors Based on Target Screening

Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences

View on ClinicalTrials.gov

Summary

This is a single-arm, open-label, single-center, dose-escalation Phase I platform study designed to evaluate the safety, tolerability, preliminary efficacy, pharmacokinetics, and pharmacodynamics of an in vivo CAR-T therapy (V001 Injection, targeting BCMA, GPRC5D, DLL3, etc.) in patients with advanced malignant tumors.

Official title: A Phase I Study of the In Vivo CAR-T Platform for Treating Advanced Malignant Tumors Based on Target Screening

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

50

Start Date

2025-11-21

Completion Date

2027-12

Last Updated

2026-02-09

Healthy Volunteers

No

Interventions

GENETIC

V001-BCMA

An in vivo CAR-T drug targeting BCMA administered intravenously

GENETIC

V001-GPRC5D

An in vivo CAR-T drug targeting GPRC5D administered intravenously

GENETIC

V001-DLL3

An in vivo CAR-T drug targeting DLL3 administered intravenously

Locations (1)

Cancer Hospital Chinese Academy of Medical Sciences 17 Panjiayuan Nanli, Chaoyang District

Beijing, Beijing Municipality, China