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NOT YET RECRUITING
NCT07395609
NA

High Frequency Stimulation to Improve Cognition, Mobility, and Affect in Individuals With Subjective Cognitive Decline

Sponsor: University of Florida

View on ClinicalTrials.gov

Summary

The goal is to determine whether three months of at least three times / week of sensory flicker stimulation improves cognition, mobility, and affect in older adults with Subjective Cognitive Decline (SCD), relative to an SCD control group receiving white noise sensory stimulation. Investigators will also determine whether the intervention slows cortical thinning and declines in brain functional network segregation and changes in blood biomarkers of Alzheimer's Disease (AD).

Key Details

Gender

All

Age Range

65 Years - 89 Years

Study Type

INTERVENTIONAL

Enrollment

60

Start Date

2026-02-15

Completion Date

2028-10-31

Last Updated

2026-02-09

Healthy Volunteers

Yes

Interventions

BEHAVIORAL

Flicker Stimulation

Investigators will combine ultrasound (≥22 kHz) and near-infrared two-photon stimulation (890-940 nm) to deliver rhythmic input in a subliminal, comfortable manner, without the side effects associated with visible flicker.

BEHAVIORAL

Sham White Noise Stimulation

The control group will receive white noise sensory stimulation rather than a constant flicker frequency.

Locations (1)

University of Florida

Gainesville, Florida, United States