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RECRUITING
NCT07396441
PHASE4

Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye

Sponsor: Universiti Sains Malaysia

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to evaluate the effects of stingless bee honey (Kelulut honey) in juvenile open-angle glaucoma patients. The study evaluates the effects on serum Interleukin 6 level(IL-6), retinal nerve fiber layer(RNFL) thickness and dry eye-related symptoms. A total of 60 participants who meet the study criteria will be randomly assigned to one of two groups. One group will consume 30 grams of Kelulut honey daily for a period of three months, while the control group will not receive honey or a placebo. Serum IL-6 level, RNFL thickness, Tear break up time (TBUT) and Schirmer Test 1 will be done before and after 90 days. Adherence to honey consumption will be monitored using a daily diary. This study aims to provide better understanding of the potential role of Kelulut honey as a supplementary therapy in patients with juvenile open-angle glaucoma.

Official title: Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye.

Key Details

Gender

All

Age Range

15 Years - 40 Years

Study Type

INTERVENTIONAL

Enrollment

60

Start Date

2026-01-15

Completion Date

2026-06-30

Last Updated

2026-02-09

Healthy Volunteers

No

Interventions

BIOLOGICAL

Stingless bee honey (Kelulut)

Kelulut is stingless bee honey, a natural biologic product produced by stinglee bee species.

Locations (4)

Hospital Raja Perempuan Zainab II

Kota Bharu, Kelantan, Malaysia

Hospital Sultan Ismail Petra

Kuala Krai, Kelantan, Malaysia

Hospital Universiti Sains Malaysia

Kubang Kerian, Kelantan, Malaysia

Hospital Sultanah Nur Zahirah

Kuala Terengganu, Terengganu, Malaysia