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Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye
Sponsor: Universiti Sains Malaysia
Summary
The goal of this clinical trial is to evaluate the effects of stingless bee honey (Kelulut honey) in juvenile open-angle glaucoma patients. The study evaluates the effects on serum Interleukin 6 level(IL-6), retinal nerve fiber layer(RNFL) thickness and dry eye-related symptoms. A total of 60 participants who meet the study criteria will be randomly assigned to one of two groups. One group will consume 30 grams of Kelulut honey daily for a period of three months, while the control group will not receive honey or a placebo. Serum IL-6 level, RNFL thickness, Tear break up time (TBUT) and Schirmer Test 1 will be done before and after 90 days. Adherence to honey consumption will be monitored using a daily diary. This study aims to provide better understanding of the potential role of Kelulut honey as a supplementary therapy in patients with juvenile open-angle glaucoma.
Official title: Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye.
Key Details
Gender
All
Age Range
15 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-01-15
Completion Date
2026-06-30
Last Updated
2026-02-09
Healthy Volunteers
No
Conditions
Interventions
Stingless bee honey (Kelulut)
Kelulut is stingless bee honey, a natural biologic product produced by stinglee bee species.
Locations (4)
Hospital Raja Perempuan Zainab II
Kota Bharu, Kelantan, Malaysia
Hospital Sultan Ismail Petra
Kuala Krai, Kelantan, Malaysia
Hospital Universiti Sains Malaysia
Kubang Kerian, Kelantan, Malaysia
Hospital Sultanah Nur Zahirah
Kuala Terengganu, Terengganu, Malaysia