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stereOtactic Body RadIothErapy for exTracranial oligomeTastAtic Breast Cancer: Multi Institutional Retrospective Database
Sponsor: Istituto Clinico Humanitas
Summary
Oligometastatic breast cancer is a condition in which breast cancer has spread to a small number of other parts of the body. Patients with this type of disease may live longer than those with more widespread metastases. In addition to standard treatments that act on the whole body, such as chemotherapy or hormonal therapy, these patients might also benefit from local treatments that directly target the cancer spots. One of these local treatments is stereotactic body radiotherapy (SBRT), a non-invasive radiation treatment that delivers high doses of radiation in a few sessions. In the past, most of the evidence about the benefit of local treatments came from surgery. More recently, there has been growing interest in SBRT because it does not require surgery. However, the results of studies so far have not been consistent.The goal of this multicenter retrospective study is to better understand whether SBRT can improve disease control and survival in patients with breast cancer that has spread to a limited number of sites outside the brain.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2025-02-25
Completion Date
2026-12-31
Last Updated
2026-02-11
Healthy Volunteers
No
Conditions
Locations (28)
Aorn San Pio
Benevento, Benevento, Italy
Humanitas Gavazzeni
Bergamo, Bergamo, Italy
Ospedale Perrino
Brindisi, BR, Italy
Spedali Civili
Brescia, BS, Italy
Responsible Research Hospital
Campobasso, CB, Italy
Azienda Ospedaliera Universitaria Careggi
Florence, Firenze, Italy
Irccs Ospedale Policlinico San Martino
Genova, Genova, Italy
A.O.U. "G. Martino" - Università degli Studi di Messina
Messina, Messina, Italy
Fondazione I.R.C.C.S Istituto Nazionale Tumori di Milano
Milan, MILANO, Italy
IEO
Milan, Milano, Italy
IRCCS Humanitas Research Humanitas
Rozzano, MILANO, Italy
IRCCS Ospedale San Raffaele
Milan, Milan, Italy
INT IRCCS Fondazione G. Pascale
Naples, Napoli, Italy
Ospedale Maggiore della Carita
Novara, NOVARA, Italy
Civico Palermo
Palermo, Palermo, Italy
Istituto Oncologico Veneto
Padova, PD, Italy
Azienda Ospedaliera Universitaria Pisana
Pisa, PI, Italy
IRCCS Centro di Riferimento Oncologico di Aviano
Aviano, Pordenone, Italy
Uo Radioterapia Aor San Carlo
Potenza, PZ, Italy
Irccs Crob
Rionero in Vulture, PZ, Italy
UOC Radioterapia Ospedale San Filippo Neri
Roma, RM, Italy
Azienda Ospedaliera San Giovanni Addolorata
Roma, RM, Italy
Fondazione Policlinico Universitario, Campus-Biomedico
Roma, Roma, Italy
Fondazione PTV Policlinico Tor Vergata
Roma, Roma, Italy
Azienda Ospedaliera Sant'Andrea
Roma, Roma, Italy
S.C. Radioterapia Oncologica ASL Taranto
Taranto, Taranto, Italy
Radioterapia Oncologica - Ospedale Sanata Chiara
Trento, TRENTO, Italy
S.C. Radioterapia Oncologica - Azienda Ospedaliera Santa Maria Terni
Terni, TR, Italy