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Early Sepsis Recognition Tool
Sponsor: KK Women's and Children's Hospital
Summary
This study seeks to develop early recognition tools specially designed for children meeting the Phoenix definition and explore implementation science aspects by investigating facilitators and barriers to adopting Phoenix sepsis criteria in clinical practice. This addresses the critical need for systemic, evidence-based approaches to paediatric sepsis identification across diverse healthcare settings in Asia.
Official title: Sepsis Optimal Recognition Toolkit in Children (SORT): An Early Recognition Tool for Children in Asia
Key Details
Gender
All
Age Range
Any - 18 Years
Study Type
OBSERVATIONAL
Enrollment
40000
Start Date
2026-02
Completion Date
2028-12
Last Updated
2026-02-11
Healthy Volunteers
No
Interventions
Application of the Phoenix Sepsis Score
Data Variables in the first 24 hours of hospital admission as per Phoenix Sepsis Score: Including that of respiratory function (PaO2:FiO2 and SpO2:FiO2 ratios, need for oxygen, high-flow, non-invasive or mechanical ventilation support), cardiovascular function (including need for vasoactive medications, lactate value and mean arterial pressure), coagulopathy (measured using platelets, International Normalized Ratio, D-dimer and Fibrinogen), neurologic dysfunction (measured with Glasgow Coma Scale and presence of fixed pupils), endocrine (blood glucose), immunologic (absolute neutrophil and absolute lymphocyte count), renal (creatinine levels) and hepatic (total bilirubin and alanine transaminase). Data from the Emergency Departments will need to be linked to inpatient records to obtain the worst values in each domain that occurred in the first 24 hours.
Locations (19)
Shanghai Children's Medical Center, Shanghai Jiaotong University
Shanghai, China
Prince of Wales Hospital, The Chinese University of Hong Kong
Hong Kong, Hong Kong
Hospital Pulau Pinang
George Town, Malaysia
Hospital Sultanah Aminah Johor Bahru
Johor Bahru, Malaysia
Hospital Tengku Ampuan Rahimah
Klang, Malaysia
Hospital Tunku Azizah (Hospital Wanita dan Kanak-Kanak Kuala Lumpur)
Kuala Lumpur, Malaysia
UKM: Hospital Tunku Ampuan Besar Tuanku Aishah Rohani
Kuala Lumpur, Malaysia
University Malaya Medical Centre (UMMC)
Kuala Lumpur, Malaysia
Hospital Umum Sarawak
Kuching, Malaysia
Hospital Sultan Idris Shah
Serdang, Malaysia
Aga Khan University
Karachi, Pakistan
King Abdullah Specialist Children's Hospital
Riyadh, Saudi Arabia
KK Women's and Children' Hospital
Singapore, Singapore
National University Hospital
Singapore, Singapore
Chang Gong Memorial Hospital
Taipei, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
King Chulalongkorn Memorial Hospital
Bangkok, Thailand
Ramathibodi Hospital, Mahidol University
Bangkok, Thailand
The National Children's Hospital
Hanoi, Vietnam