Clinical Research Directory
Browse clinical research sites, groups, and studies.
Markers of Bone Destruction and Oxidative Stress in Peri-implantitis
Sponsor: Saglik Bilimleri Universitesi
Summary
The aim of this study is to evaluate and compare the levels of bone resorption (RANKL, OPG) and oxidative stress (Nitrotyrosine, NQO1) markers, along with pro-inflammatory cytokines (IL-1β), in the saliva and peri-implant sulcular fluid (PISF) of patients with peri-implantitis, periodontitis, and healthy individuals. The study seeks to determine the diagnostic value of these biomarkers in the early detection and progression of peri-implant diseases.
Official title: Evaluation of Bone Destruction and Oxidative Stress Markers in Saliva and Peri-implant Sulcus Fluid in Peri-implantitis
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
80
Start Date
2026-02-15
Completion Date
2026-09-15
Last Updated
2026-02-09
Healthy Volunteers
Yes