Clinical Research Directory

Inclusion Criteria: * Signed Informed Consent Form. * Male and female subjects aged 18-70 years, inclusive. * Availability for the twelve-week duration of the clinical research study. * Good general health based on the opinion of the study investigator * Minimum of 20 permanent natural teeth (excluding third molars). * Initial gingivitis index of at least 1.0 as determined by the use of the Loe and Silness Gingival Index. * Initial mean plaque index of at least 0.6 as determined by Rustogi Modification of the Navy plaque index. Exclusion Criteria: * Presence of orthodontic appliances; * Presence of partial removable dentures; * Oral pathology, chronic disease or tumor(s) of the soft or hard tissues of the oral cavity; 4. Advanced periodontal disease (purulent exudate, tooth mobility, and/or extensive loss of periodontal attachment or alveolar bone); * Five or more carious lesions requiring immediate restorative treatment; * Use of anticonvulsants, sedatives, tranquilizers, anti-inflammatory or daily analgesics within one month prior to the start of the study or scheduled to start such intake during the course of the study; * Use of antibiotics any time during the one-month period prior to entry into the study; * Ongoing use of medications known to affect the gingival tissues (i.e. calcium channel blockers, phenytoin, cyclosporine) and/or on any prescription medicines that might interfere with the study outcome; * Participation in any other clinical study; * Self-reported pregnancy and/or breastfeeding; * Dental prophylaxis within the past three weeks prior to baseline examinations; * Current allergies and/or history of allergic reactions to oral care products, personal care consumer products, or any of their ingredients; * An existing medical condition that prohibits eating and/or drinking for periods up to 4 hours; * Current smokers and/or a history of alcohol or drug abuse