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Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy
Sponsor: National Cancer Center, Korea
Summary
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and often persistent adverse effect of oxaliplatin- and paclitaxel-based chemotherapy. While exercise is frequently recommended for patients with CIPN, it remains unclear whether exercise mitigates neuropathic injury itself or primarily improves physical function and quality of life. This randomized controlled trial evaluates the effects of exercise on CIPN during and after chemotherapy. Patients receiving oxaliplatin for colorectal cancer or paclitaxel for gynecologic cancer are randomized to an exercise intervention or usual-care control. Neuropathy severity is assessed using objective neurophysiological measures, blood biomarkers, and validated clinical and patient-reported outcomes.
Official title: A Randomized Controlled Trial Evaluating the Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy in Patients Treated With Oxaliplatin or Paclitaxel
Key Details
Gender
All
Age Range
19 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
140
Start Date
2026-02-03
Completion Date
2027-12-31
Last Updated
2026-02-10
Healthy Volunteers
No
Conditions
Interventions
Exercise Intervention
A structured home-based exercise program performed during chemotherapy and for up to three months after completion of chemotherapy. The program includes aerobic and strengthening exercises and is designed to be safe and feasible during active cancer treatment. Adherence is monitored through regular telephone follow-up.
Usual Care
Standard oncologic care and general education regarding chemotherapy-induced peripheral neuropathy, without a structured exercise program.
Locations (1)
National Cancer Center
Goyang, Gyeonngi, South Korea