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RECRUITING
NCT07401186
NA

Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways

Sponsor: Peter C. Gerszten, MD

View on ClinicalTrials.gov

Summary

The goal of this study is to assess cervical (neck) reflexes by intra-operatively stimulating the neck nerve roots to evoke motor responses through their connections to spinal motoneurons. This data is critical to reveal changes to the spinal sensory modulating circuitry in neurological disorders like stroke.

Official title: Stimulation Evoked Primary Afferent Depolarization to Modulate Sensory Transmission to Spinal Motoneurons and the Sensory Cortex

Key Details

Gender

All

Age Range

21 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

15

Start Date

2026-05

Completion Date

2028-01

Last Updated

2026-03-05

Healthy Volunteers

Yes

Interventions

DEVICE

Bipolar Neural Stimulation Electrode

All individuals enrolled in this study will receive electrical stimulation to the dorsal cervical spinal nerves using the FDA-cleared bipolar stimulating electrode routinely used as standard-of-care to monitor neural function, during which muscle activities will be recorded through intramuscular electromyography (EMGs), and sensory evoked cortical local field potentials (SSEPs) will be acquired simultaneously to characterize properties of the spinal sensory pathways.

Locations (1)

University of Pittsburgh

Pittsburgh, Pennsylvania, United States