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Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways
Sponsor: Peter C. Gerszten, MD
Summary
The goal of this study is to assess cervical (neck) reflexes by intra-operatively stimulating the neck nerve roots to evoke motor responses through their connections to spinal motoneurons. This data is critical to reveal changes to the spinal sensory modulating circuitry in neurological disorders like stroke.
Official title: Stimulation Evoked Primary Afferent Depolarization to Modulate Sensory Transmission to Spinal Motoneurons and the Sensory Cortex
Key Details
Gender
All
Age Range
21 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2026-05
Completion Date
2028-01
Last Updated
2026-03-05
Healthy Volunteers
Yes
Conditions
Interventions
Bipolar Neural Stimulation Electrode
All individuals enrolled in this study will receive electrical stimulation to the dorsal cervical spinal nerves using the FDA-cleared bipolar stimulating electrode routinely used as standard-of-care to monitor neural function, during which muscle activities will be recorded through intramuscular electromyography (EMGs), and sensory evoked cortical local field potentials (SSEPs) will be acquired simultaneously to characterize properties of the spinal sensory pathways.
Locations (1)
University of Pittsburgh
Pittsburgh, Pennsylvania, United States