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RECRUITING

NCT07402200

Study of Indoor Air Pollutants and Their Impact in Children's Health and Wellbeing

Sponsor: University Hospital, Montpellier

View on ClinicalTrials.gov

Summary

The goal of this study is to identify and assess in real time the impact of the combined action of various types of air and dust pollutants within a classroom on children's health and quality of life, particularly regarding atopic/allergic diseases in children, and on potential exposure to pollutants at home. Participants will answer questionnaires regarding their health and medications, undergo allergy tests, perform non-invasive lung function tests and check blood oxygen levels.

Official title: Disrupting Noxious Synergies of Indoor Air Pollutants and Their Impact in Childhood Health and Wellbeing, Using Advanced Intelligent Multisensing and Green Interventions: an Interventional Study in a Sub-group of Schoolchildren

Key Details

Gender

All

Age Range

8 Years - 12 Years

Study Type

INTERVENTIONAL

Enrollment

100

Start Date

2026-02-04

Completion Date

2026-06

Last Updated

2026-02-11

Healthy Volunteers

Conditions

Allergy

Interventions

OTHER

Standardized questionnaires

Baseline questionnaires for cases and follow-up questionnaires for cases and controls will be completed to collect data on sociodemographic characteristics, health outcomes, potential risk factors, lifestyle, and living environment.

OTHER

Lung function tests

All participants, including cases and controls, will undergo comprehensive spirometry testing, pulse oximetry assessment, and fractional exhaled nitric oxide (FeNO) measurement.

DIAGNOSTIC_TEST

Prick tests

Cases and controls will undergo skin prick testing for common allergens, including house dust mites, cat, dog, Alternaria, cypress, birch, plane tree (Platanus), grass, latex, olive tree, ragweed, and mugwort,...

OTHER

Biological samples

Subjects and their parents/guardians will be given the option to provide blood, urine, and nasopharyngeal samples.

DEVICE

Portable sensors

Up to 10 subjects ( with their parents/guardians consent) will be given the option to use CANARIN devices, to monitor at the individual level exposures to air pollutants (PM and VOC) and other environmental factors (temperature, humidity, pressure) in and outside school.

Inclusion Criteria: * Child included in the SynAir-G observational study * Child and caregiver(s) willing to follow the study procedures * Written informed consent from the child's parents/guardians * For case group, at least one positive answer (yes) to any of the following questions and for control group, negative answers to all the following questions based on the baseline questionnaire administered in the SynAir-G observational study, as shown below.: a. General health i. Does your child have any health problems (if yes to asthma, allergic rhinitis /rhino-conjunctivitis, atopic dermatitis)? b. Asthma i. Has your child ever had wheezing or whistling in the chest in the past 12 months? ii. In the past 12 months, has your child's chest sounded wheezy during or after exercise? iii. In the past 12 months, has your child had a dry cough at night, apart from a cough associated with a cold or chest infection? c. Rhinitis i. In the past 12 months has your child had a problem with sneezing, or a runny, or blocked nose when she/he DID NOT have a cold or the flu? d. Eczema (both answers yes) i. Has your child had this itchy rash at any time in the past 12 months? If so, has this itchy rash at any time affected any of the following places: the folds of the elbows, behind the knees, in front of the ankles, under the buttocks, or around the neck, ears or eyes? e. Food allergy i. Has your child had diagnosed food allergy during last 12 months? * For case group: Diagnosis of asthma/allergic rhinitis/eczema/food allergy (based on SYNAIR-G baseline questionnaire), active during the past year. * For control group: absence of diagnosis of asthma/allergic rhinitis/eczema/food allergy (based on SYNAIR-G baseline questionnaire) Exclusion Criteria: * Child or child's parents/guardians who: 1. Refuse to participate in the project / to give informed consent. 2. Do not want to follow the protocol procedures. 3. Do not read or/and write in French. 4. Plan a long stay outside the region that does not allow them to follow the visit plan. 5. The child is not affiliated to the French social security service

Locations (1)

CHU Montpellier

Montpellier, France

Clinical Research Directory

Study of Indoor Air Pollutants and Their Impact in Children's Health and Wellbeing

Summary

Key Details

Conditions

Interventions

Eligibility Criteria

Locations (1)