Clinical Research Directory

Main Inclusion Criteria： * Age ≥ 18 years old * Clinically diagnosed with chronic heart failure * Receiving guideline directed medical and device therapy (GDMT) for heart failure * Left ventricular ejection fraction (LVEF) ≤ 40% assessed by echocardiography * New York Heart Association (NYHA) functional class II or III, with NYHA II criteria met simultaneously; for NYHA III, at least one of the following must be satisfied: 1. At least one hospitalization for heart failure within the past 12 months; 2. Elevated BNP or NT-proBNP within 3 months prior to enrollment (under normal sinus rhythm, NT-proBNP \> 900 pg/mL; under atrial fibrillation, NT-proBNP \> 1500 pg/mL; under normal sinus rhythm, BNP \> 300 pg/mL; under atrial fibrillation, BNP \> 500 pg/mL; BNP not applicable if the patient is using ARNI); * Able to perform 6-minute walk test (6MWT), with a distance between 100 meters and 450 meters Main Exclusion Criteria * Currently in an acute decompensation of chronic heart failure (hospitalization within 2 weeks prior to enrollment), refractory end-stage heart failure, or on the waiting list for heart transplantation (including LVAD indication); * BMI \> 40 kg/m² or \< 18.5 kg/m²; * Systolic blood pressure \<90 or ≥160 mmHg * Moderate or severe aortic or mitral stenosis, or planned during the trial intervention for severe regurgitation of the aortic, mitral, tricuspid, or pulmonary valves; * Coronary artery disease requiring revascularization; * Hypertrophic cardiomyopathy, active myocarditis, cardiac tamponade or large pericardial effusion, congenital heart disease, or other causes of heart failure * History of stroke, transient ischemic attack (TIA), deep vein thrombosis (DVT), or pulmonary emboli within the past 3 months * Severe chronic lung disease requiring oxygen therapy or long-term corticosteroids; * Surgery involving atrial septal puncture within 3 months before enrollment (e.g., mitral repair, atrial fibrillation ablation, LAA closure); * Significant RV dysfunction - TAPSE \<12mm or RVFAC ≤25% * eGFR \<25 ml/min/1.73 m\^2