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RECRUITING
NCT07402915
PHASE1

Drug-drug Interaction Study With AZD5335 and Itraconazole in Participants With Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Sponsor: AstraZeneca

View on ClinicalTrials.gov

Summary

The purpose of this study is to assess the effect of itraconazole on the pharmacokinetics (PK) of AZ14170132.

Official title: An Open-label, Fixed Sequence Phase I Study to Evaluate the Effect of Itraconazole (a Strong CYP3A Inhibitor) on the Pharmacokinetics of AZ14170132, the TOP1 Inhibitor Payload of the Antibody Drug Conjugate AZD5335, in Participants With Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Key Details

Gender

FEMALE

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

24

Start Date

2026-01-26

Completion Date

2027-10-15

Last Updated

2026-04-02

Healthy Volunteers

No

Interventions

DRUG

AZD5335

AZD5335 will be administered as IV infusion.

DRUG

Itraconazole

Itraconazole capsule will be administered orally.

Locations (9)

Research Site

Batumi, Georgia

Research Site

Tbilisi, Georgia

Research Site

Tbilisi, Georgia

Research Site

Dublin, Ireland

Research Site

Lisbon, Portugal

Research Site

Barcelona, Spain

Research Site

Logroño, Spain

Research Site

Madrid, Spain

Research Site

Madrid, Spain