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Drug-drug Interaction Study With AZD5335 and Itraconazole in Participants With Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Sponsor: AstraZeneca
Summary
The purpose of this study is to assess the effect of itraconazole on the pharmacokinetics (PK) of AZ14170132.
Official title: An Open-label, Fixed Sequence Phase I Study to Evaluate the Effect of Itraconazole (a Strong CYP3A Inhibitor) on the Pharmacokinetics of AZ14170132, the TOP1 Inhibitor Payload of the Antibody Drug Conjugate AZD5335, in Participants With Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2026-01-26
Completion Date
2027-10-15
Last Updated
2026-04-02
Healthy Volunteers
No
Interventions
AZD5335
AZD5335 will be administered as IV infusion.
Itraconazole
Itraconazole capsule will be administered orally.
Locations (9)
Research Site
Batumi, Georgia
Research Site
Tbilisi, Georgia
Research Site
Tbilisi, Georgia
Research Site
Dublin, Ireland
Research Site
Lisbon, Portugal
Research Site
Barcelona, Spain
Research Site
Logroño, Spain
Research Site
Madrid, Spain
Research Site
Madrid, Spain