Clinical Research Directory
Browse clinical research sites, groups, and studies.
Wellbeing and Survival Improvement With Event Reduction by Ablation for Atrial Fibrillation in the Very Elderly
Sponsor: Beijing Anzhen Hospital
Summary
The WISER-AF trial is a multicenter, double-blind, sham-controlled, randomized controlled trial. It aims to evaluate the efficacy and safety of catheter ablation compared to a sham procedure in improving the quality of life (SF-36 score) in very elderly patients (aged ≥80 years) with symptomatic atrial fibrillation over a 6-month follow-up period.
Official title: Wellbeing and Survival Improvement With Event Reduction by Ablation for Atrial Fibrillation in the Very Elderly (WISER-AF)
Key Details
Gender
All
Age Range
80 Years - Any
Study Type
INTERVENTIONAL
Enrollment
182
Start Date
2026-01-30
Completion Date
2028-12-30
Last Updated
2026-02-11
Healthy Volunteers
No
Conditions
Interventions
Catheter Ablation
Patients undergo PVI (for paroxysmal AF) or PVI +linear ablation+EI-VOM(for persistent AF) using pulsed field ablation catheters. All patients will wear eye masks and headphones with music during the procedure.
Sham Control
Patients undergo femoral vein puncture and catheter placement. Phrenic nerve stimulation is performed to mimic procedural sensations. No ablation energy is delivered. All patients will wear eye masks and headphones with music during the procedure. Patients remain in the lab for at least 80 minutes.
Locations (1)
Beijing Anzhen Hospital, Capital Medical University, Beijing, China
Beijing, China