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Rewiring the Brain-Immune Axis for Chronic Pain Using Transcranial Magnetic Stimulation in Psoriatic Arthritis
Sponsor: NHS Greater Glasgow and Clyde
Summary
Despite advances in immunomodulatory therapies, many Psoriatic arthritis (PsA) patients experience persistent pain unrelated to clinical active joint inflammation. Recent evidence suggests the Inferior Parietal Lobule (IPL) serves as a neuroimmune hub linking central neural activity with peripheral immune dysregulation. In a prior feasibility study, a single L-IPL-targeted TMS session reduced pain and altered immune signalling in inflammatory arthritis by reducing STAT3 phosphorylation in circulating monocytes. This study builds on those findings by evaluating whether rTMS over 4 weeks can induce sustained immune reprogramming while providing meaningful pain relief.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-03-01
Completion Date
2028-03-28
Last Updated
2026-02-11
Healthy Volunteers
No
Conditions
Interventions
Active Repetitive Transcranial Magnetic Stimulation (rTMS)
rTMS delivered to the left inferior parietal lobule at 10 Hz, 90% resting motor threshold, 1200 pulses per session, for 12 sessions over 4 weeks.
Control Repetitive Transcranial Magnetic Stimulation (rTMS)
rTMS delivered to the cranial vertex using identical stimulation parameters to the active arm, serving as a control condition.
Locations (1)
Queen Elizabeth University Hospital
Glasgow, Scotland, United Kingdom