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ENROLLING BY INVITATION
NCT07405463
NA

Effects of tDCS on Fear Reversal in Patients With Anxiety Disorders

Sponsor: Jingchu Hu

View on ClinicalTrials.gov

Summary

This study evaluates the effects of single-session Transcranial Direct Current Stimulation (tDCS) on fear reversal learning in patients with anxiety disorders. Participants will be randomized into four groups to receive either active stimulation targeting specific brain regions (right DLPFC or vmPFC), an active control stimulation, or sham stimulation. The main goal is to determine if modulating these brain areas can improve the ability to update safety and threat associations.

Official title: A Randomized, Double-Blind, Controlled Study of Transcranial Direct Current Stimulation Intervention on Fear Reversal in Patients With Anxiety Disorders

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

140

Start Date

2025-12-01

Completion Date

2028-12-01

Last Updated

2026-02-12

Healthy Volunteers

Yes

Interventions

DEVICE

Cathodal tDCS (rDLPFC)

Current intensity: 2.0 mA. Duration: 25 minutes. Cathode placed over F4 (10-20 system), Anode over contralateral deltoid.

DEVICE

Anodal tDCS (vmPFC)

Current intensity: 2.0 mA. Duration: 25 minutes. Anode placed over Fpz (10-20 system), Cathode over Oz.

DEVICE

Sham tDCS

Current ramps up for 30 seconds and then fades to zero to mimic skin sensation, with no sustained current for the rest of the 25 minutes.

DEVICE

Anodal tDCS (lDLPFC)

Current intensity: 2.0 mA. Duration: 25 minutes. Anode placed over F3 (10-20 system), Cathode over contralateral deltoid.

Locations (1)

Shenzhen Kangning Hospital

Guangzhou, Guangdong, China