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Effects of tDCS on Fear Reversal in Patients With Anxiety Disorders
Sponsor: Jingchu Hu
Summary
This study evaluates the effects of single-session Transcranial Direct Current Stimulation (tDCS) on fear reversal learning in patients with anxiety disorders. Participants will be randomized into four groups to receive either active stimulation targeting specific brain regions (right DLPFC or vmPFC), an active control stimulation, or sham stimulation. The main goal is to determine if modulating these brain areas can improve the ability to update safety and threat associations.
Official title: A Randomized, Double-Blind, Controlled Study of Transcranial Direct Current Stimulation Intervention on Fear Reversal in Patients With Anxiety Disorders
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
140
Start Date
2025-12-01
Completion Date
2028-12-01
Last Updated
2026-02-12
Healthy Volunteers
Yes
Conditions
Interventions
Cathodal tDCS (rDLPFC)
Current intensity: 2.0 mA. Duration: 25 minutes. Cathode placed over F4 (10-20 system), Anode over contralateral deltoid.
Anodal tDCS (vmPFC)
Current intensity: 2.0 mA. Duration: 25 minutes. Anode placed over Fpz (10-20 system), Cathode over Oz.
Sham tDCS
Current ramps up for 30 seconds and then fades to zero to mimic skin sensation, with no sustained current for the rest of the 25 minutes.
Anodal tDCS (lDLPFC)
Current intensity: 2.0 mA. Duration: 25 minutes. Anode placed over F3 (10-20 system), Cathode over contralateral deltoid.
Locations (1)
Shenzhen Kangning Hospital
Guangzhou, Guangdong, China