Clinical Research Directory

Inclusion Criteria: 1. Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures 2. At least 18 years of age at the time of signing the Informed Consent Form 3. Non-permanent atrial fibrillation or ectopic atrial tachycardia with rhythm control strategy, documented on any modality in the 1 year preceding the consent date 4. Stable coronary artery disease without argument, defined as: 1. Prior percutaneous coronary intervention; OR 2. Prior revascularised ACS or coronary artery bypass surgery \> 3 months at enrolment; OR 3. Invasive coronary angiography demonstrating coronary atherosclerosis, defined as ≥50% diameter stenosis in at least one major epicardial coronary artery; OR 4. Coronary CT scan showing coronary stenosis CAD-RADS stage ≥ 3 on, including CAD-RADS stages 4 and 5 in the absence of ischemia on exercise testing, myocardial perfusion imaging (MIBI), stress cardiac MRI, or fractional flow reserve. 5. LVEF ≥ 45% documented on any imaging modality\* Exclusion Criteria: 1. LVEF \< 45% 2. NYHA class III or IV congestive heart failure 3. Active treatment with amiodarone 4. History of intolerance of flecainide or both sotalol and amiodarone 5. Unstable angina or inducible ischemia on exercise stress testing, myocardial perfusion imaging, stress cardiac MRI, or fractional flow reserve performed for clinical indications 6. Baseline QRS duration ≥ 120 ms, unless a functioning pacemaker is present 7. Baseline corrected QT interval (Fridericia) ≥ 500 ms 8. Pre-existing advanced AV block (second-, or third-degree) 9. Pre-existing sick sinus syndrome or sinus bradycardia \<50 bpm 10. Known channelopathy 11. Contra-indication to AV-slowing agents, including beta-blockers, diltiazem or verapamil 12. Atrial fibrillation due to reversible cause 13. Active intracardiac thrombus 14. Acute coronary syndrome during the 3-month period preceding the consent date 15. Cardiac surgery, including coronary artery bypass surgery, during the 3-month period preceding the consent date or planned at a future date at the time of consent 16. Moderate or severe congenital heart disease as per 2020 ESC guidelines 17. Hypertrophic cardiomyopathy (septal or posterior wall thickness \>1.5 cm) 18. Significant chronic kidney disease (eGFR \<40 mL/min) 19. Life expectancy less than 1 year 20. Female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using an adequate, highly effective contraceptive 21. Inability to provide written informed consent, including decision-making incapacity due to cognitive impairment or other medical or psychiatric conditions that preclude adequate understanding of the study and its procedures. 22. Participation in an interventional Trial with an investigational medicinal product (IMP) or device