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Exploring the Use of Genetic and Behavioural Data in Tailoring Dietary and Lifestyle Support
Sponsor: Alexandra King
Summary
Personalised nutrition approaches typically rely on static information such as health status, lifestyle and genetic data. However, adherence often remains low because daily behaviours are influenced by psychological states, motivation and real-time barriers. There is growing interest in whether integrating behavioural signals and timely prompts could strengthen engagement. The purpose of this study is to explore whether incorporating psychological adaptation and just-in-time behavioural prompts leads to better adherence to a personalised nutrition programme compared with commonly used personalised approach (combining health, lifestyle and genetics data without psycho-behavioural adaptation). Using a six-week n-of-1 randomised trial design implemented across multiple participants, the research will also assess the feasibility of delivering this adaptive support in a free-living environment, as well as participants' engagement, acceptability and perceived usefulness. These findings will inform the development of an adaptive personalised nutrition AI agent.
Official title: Exploring the Use of Genetic and Behavioural Data in Tailoring Dietary and Lifestyle Support: An n=1 Randomised Trial
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2026-03
Completion Date
2026-06
Last Updated
2026-02-12
Healthy Volunteers
Yes
Interventions
Psychology-tailored message
Participants receive the same nutritional and lifestyle content, but daily goals are adapted based on: Stable Traits * Big Five personality * Health locus of control * Optimism bias * Delay discounting * Self-determination * Stress/anxiety baseline * Habit awareness * Values/motivations * Reward preferences Daily State * Morning energy rating (1-5) * Expected barriers * Context (home vs office vs weekend) Communication Preferences * tone (coachy, compassionate, factual, brief) * message length (low/medium/high) * mode (text, voice, image) Environmental and Social Context (e.g., Friday office snacks, partner-driven late dinners) Daily personalisation influences: * difficulty level of the daily goal * specific behaviour change technique (BCT) chosen (e.g., action planning vs implementation intention vs coping planning) * tone, structure and timing of the message * reinforcement style The nutrition content remains identical; only HOW it is delivered changes.
Neutral message
Participants receive: * One fixed daily behaviour goal, aligned with the weekly pillar * Personalised only according to diet, lifestyle, health status and genetics * Delivered at a pre-selected time chosen by the participant (e.g., 8:30-10:00) No adaptation is made based on: * psychological traits * daily mood/energy * anticipated or reported barriers * communication preferences (tone, length, mode) This reflects current "gold standard" personalised nutrition: personalised by biology and lifestyle, but not by psychology or dynamic states.
Locations (1)
St Mary's University
Twickenham, Middlesex, United Kingdom