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ACTIVE NOT RECRUITING
NCT07408180
NA

Exploratory Randomized, Controlled, Dose-response Study on the Impact of Nicotine From Five Variants of a Nicotine Tablet (NICOTINE TABLET) on Attention

Sponsor: Philip Morris Products S.A.

View on ClinicalTrials.gov

Summary

This study aims to provide initial insights into the impact of orally delivered nicotine on attentional performance in adult occasional users of nicotine pouches. Nicotine will be administered via a dissolvable tablet for approximately 10 minutes. The main objective of this exploratory study is to characterize the effect of nicotine on attentional performance, using metrics derived from Continuous Performance Test (CPT). Additionally, a second CPT assessment will be conducted two hours after the first administration to explore the potential sustained effects of nicotine on attention as an exploratory objective.

Official title: Impact of Nicotine From Five Variants of a Nicotine Tablet on Attention in Adult Users of Nicotine Pouches: An Exploratory, Randomized, Controlled, Double-blind, Crossover Study

Key Details

Gender

All

Age Range

19 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

40

Start Date

2025-10-28

Completion Date

2026-04-23

Last Updated

2026-02-18

Healthy Volunteers

Yes

Conditions

Interventions

OTHER

NICOTINE TABLET-0mg

NICOTINE TABLET (nicotine content 0mg; Mint flavor)

OTHER

NICOTINE TABLET-0.5mg

NICOTINE TABLET (nicotine content 0.5mg; Mint flavor)

OTHER

NICOTINE TABLET-1.0mg

NICOTINE TABLET (nicotine content 1.0mg; Mint flavor)

OTHER

NICOTINE TABLET-1.5mg

NICOTINE TABLET (nicotine content 1.5mg; Mint flavor)

OTHER

NICOTINE TABLET-2.0mg

NICOTINE TABLET (nicotine content 2.0mg; Mint flavor)

Locations (1)

CTC Clinical Trial Consultants AB

Uppsala, Sweden