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Exploratory Randomized, Controlled, Dose-response Study on the Impact of Nicotine From Five Variants of a Nicotine Tablet (NICOTINE TABLET) on Attention
Sponsor: Philip Morris Products S.A.
Summary
This study aims to provide initial insights into the impact of orally delivered nicotine on attentional performance in adult occasional users of nicotine pouches. Nicotine will be administered via a dissolvable tablet for approximately 10 minutes. The main objective of this exploratory study is to characterize the effect of nicotine on attentional performance, using metrics derived from Continuous Performance Test (CPT). Additionally, a second CPT assessment will be conducted two hours after the first administration to explore the potential sustained effects of nicotine on attention as an exploratory objective.
Official title: Impact of Nicotine From Five Variants of a Nicotine Tablet on Attention in Adult Users of Nicotine Pouches: An Exploratory, Randomized, Controlled, Double-blind, Crossover Study
Key Details
Gender
All
Age Range
19 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-10-28
Completion Date
2026-04-23
Last Updated
2026-02-18
Healthy Volunteers
Yes
Conditions
Interventions
NICOTINE TABLET-0mg
NICOTINE TABLET (nicotine content 0mg; Mint flavor)
NICOTINE TABLET-0.5mg
NICOTINE TABLET (nicotine content 0.5mg; Mint flavor)
NICOTINE TABLET-1.0mg
NICOTINE TABLET (nicotine content 1.0mg; Mint flavor)
NICOTINE TABLET-1.5mg
NICOTINE TABLET (nicotine content 1.5mg; Mint flavor)
NICOTINE TABLET-2.0mg
NICOTINE TABLET (nicotine content 2.0mg; Mint flavor)
Locations (1)
CTC Clinical Trial Consultants AB
Uppsala, Sweden