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Persistence of Sensitization to Contrast Media
Sponsor: University Hospital, Montpellier
Summary
The study aims to evaluate the persistence of IgE-mediated allergy to contrast media (CM) after a second exposure in patients who tested positive at both the first and second evaluations for CM allergy. It also aims to analyze the risk factors associated with the persistence of IgE-mediated sensitization after the second allergological assessment.
Official title: Evolution of IgE-mediated Sensitization to Contrast Media in Allergic Patients Diagnosed by Positive Skin Tests
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2026-02
Completion Date
2028-02
Last Updated
2026-02-13
Healthy Volunteers
No
Conditions
Interventions
Skin testing
Commercial contrast media will be used to perform skin prick testing or intradermal testing with 0.02-0.05 mL of allergenic solution. If not previously performed, a standard panel of prick tests with environmental allergens will be used to assess atopic status. Positive (histamine 10 mg/mL) and negative (saline) controls will be included. Skin testing will begin with prick tests, starting at the dilution that was positive during the initial evaluation. If negative, testing will proceed with intradermal injections using increasing concentrations until a positive response is observed. Once a positive result is obtained, skin testing for that contrast medium will be discontinued. A prick test will be considered positive if a wheal ≥3 mm with erythema and pruritus appears after 15 minutes. An intradermal test will be considered positive if a wheal ≥3 mm with erythema and pruritus appears after 20 minutes.
Baseline serum tryptase measurement
Seven milliliters of venous blood will be collected for baseline serum tryptase measurement.
Locations (1)
CHU Montpellier
Montpellier, France