Clinical Research Directory

Inclusion Criteria: * Females aged ≥ 18 years, regardless of menopausal status. * Diagnosis of HR+/HER2- breast cancer. * Currently receiving or scheduled to receive CDK4/6 inhibitor therapy. * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2. * No history of severe psychiatric disorders (e.g., bipolar disorder, schizophrenia). * Baseline psychological state sufficient to understand and participate in psychological interventions. * Currently engaged in a rehabilitation plan, including exercise therapy and physical therapy. * Willingness to provide written informed consent. * Capability to perform online operations via smartphone or computer. Exclusion Criteria: * Severe complications (e.g., heart disease, severe hepatic or renal dysfunction) that render the patient unable to tolerate CDK4/6i therapy. * History of severe psychiatric illness (e.g., severe depression, bipolar disorder, or schizophrenia) that precludes self-assessment. * Other malignant tumors within the past 5 years (excluding specific cured carcinomas). * Pregnant or breastfeeding women. * Positive baseline pregnancy test for women of childbearing potential. * Inability to adapt to or intolerance of the AI virtual doctor's intervention formats. * Any other condition that the investigator deems unsuitable for participation in the study.