Clinical Research Directory

Inclusion Criteria (Ureteral Stricture Group): Age between 18 and 75 years, regardless of gender. Diagnosis of ureteral stricture confirmed by clinical symptoms and imaging (e.g., CT, IVP, or retrograde pyelography) or ureteroscopy. The patient is scheduled for or undergoing standard clinical evaluation/treatment for ureteral stricture. Willingness to provide stool, urine, and blood samples. Informed consent signed by the participant or their legal representative. Inclusion Criteria (Healthy Control Group): Age- and sex-matched volunteers (18-75 years). No history of ureteral stricture, urinary tract obstruction, or significant renal disease. Physical examination and laboratory tests (renal function, routine urine analysis) are within normal limits. Exclusion Criteria (Applicable to Both Groups): Use of antibiotics, probiotics, prebiotics, or antifungal medications within the 4 weeks prior to sample collection. History of chronic gastrointestinal diseases (e.g., Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS), or chronic diarrhea). Known malignant tumors of the urinary tract or other systemic malignancies. History of major abdominal or urinary tract surgery within the last 3 months (excluding the current planned procedure for patients). Presence of severe systemic diseases, including uncontrolled diabetes, severe hepatic dysfunction, or end-stage heart failure. Pregnancy or breastfeeding. Any other condition that, in the opinion of the investigator, may interfere with the microbiome or metabolomic analysis.