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Resistance Training Adaptations and Caffeine Intake
Sponsor: Istanbul University - Cerrahpasa
Summary
This randomized, double-blind, placebo-controlled crossover trial investigates the effects of three different caffeine supplementation strategies on resistance training-induced adaptations in 180 caffeine-naive, inactive young adult males. Participants will undergo two 4-week supervised resistance training programs separated by a 2-week washout/crossover period. The three caffeine strategies are: (1) constant daily low-moderate dosing (3 mg/kg/day), (2) gradually escalating dose (3 to 6 mg/kg across weeks), and (3) training-day-only caffeine (3 mg/kg/day). Primary outcomes include non-invasive measures of integrated anabolism and hypertrophy (D2O-derived plasma proteomic fractional synthesis rate, DXA muscle volume) and strength metrics. Secondary outcomes include hormonal responses (insulin, cortisol, testosterone, IGF-1), sleep/recovery parameters, and adverse effects.
Official title: Study of Different Caffeine Supplementation Strategies on Resistance Training-Induced Adaptations
Key Details
Gender
MALE
Age Range
18 Years - 30 Years
Study Type
INTERVENTIONAL
Enrollment
180
Start Date
2026-02-20
Completion Date
2026-04-20
Last Updated
2026-02-13
Healthy Volunteers
Yes
Interventions
Caffeine (Constant Daily Dose)
Oral caffeine capsule at 3 mg/kg body weight, consumed daily approximately 60 minutes before training sessions (on training days) or at the same time of day (on rest days).
Placebo (Constant Daily Dose)
Identical-appearing placebo capsule consumed at the same times as the caffeine intervention.
Caffeine (Escalating Dose)
Oral caffeine starting at 3 mg/kg/day and increasing incrementally to reach 6 mg/kg/day by week 4.
Placebo (Escalating Dose)
Placebo capsule daily for 4 weeks with simulated dose escalation protocol, then crossover to escalating caffeine after 2-week washout.
Caffeine (Training Days Only)
Oral caffeine capsule at 3 mg/kg body weight, consumed only on training days approximately 60 minutes before exercise.
Placebo (Training Days Only)
Placebo capsule only on training days for 4 weeks, then crossover to caffeine after 2-week washout.
Locations (1)
Istanbul University-Cerrahpasa, Faculty of Sport Sciences Performance Laboratory
Istanbul, Avcilar, Turkey (Türkiye)