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Resistance Training Adaptations and Caffeine Intake
Sponsor: Istanbul University - Cerrahpasa
Summary
This parallel-group, randomized, double-blind, placebo-controlled trial investigates the effects of three different caffeine supplementation strategies on resistance training-induced adaptations in 120 caffeine-naive, inactive young adult males. Participants will undergo a 10-week supervised resistance training program. The four supplementation strategies are: (1) constant daily low-moderate dosing (4 mg/kg/day), (2) gradually escalating dose (2 to 6 mg/kg across weeks), (3) training-day-only caffeine (4 mg/kg/day), and (4) placebo. Primary outcomes include maximal strength, body composition (lean body mass and fat mass), skeletal muscle thickness, and training volume progression. Secondary outcomes include muscular endurance, jump height, flight-time-to-contraction-time (FT:CT) ratio, mechanistic/biological variables (epinephrine, norepinephrine, cortisol, testosterone, creatine kinase, IGF-1), rate of perceived exertion, sleep/recovery parameters, and adverse effects.
Official title: Study of Different Caffeine Supplementation Strategies on Resistance Training-Induced Adaptations
Key Details
Gender
MALE
Age Range
18 Years - 30 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2026-02-20
Completion Date
2026-06-07
Last Updated
2026-07-14
Healthy Volunteers
Yes
Interventions
Caffeine (Constant Daily Dose)
Oral caffeine capsule at 4 mg/kg body weight, consumed daily approximately 60 minutes before training sessions (on training days) or at the same time of day (on rest days).
Caffeine (Escalating Dose)
• Oral caffeine starting at 2 mg/kg/day and increasing incrementally to reach 6 mg/kg/day by week 10.
Caffeine (Training Days Only)
Oral caffeine capsule at 4 mg/kg body weight, consumed only on training days approximately 60 minutes before exercise.
placebo capsule
Oral placebo capsule (250 mg cellulose), consumed daily approximately 60 minutes before training sessions (on training days) or at the same time of day (on rest days).
Locations (1)
Istanbul University-Cerrahpasa, Faculty of Sport Sciences Performance Laboratory
Istanbul, Avcilar, Turkey (Türkiye)