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BRIDGE - Blocking Receptor of IL-1β for Donor Graft Edema Reduction
Sponsor: Northwestern University
Summary
This study will determine if primary graft dysfunction (which causes low blood oxygen levels and fluid or inflammation in the lungs) after lung transplant can be prevented through the use of the study drug (IL-1 receptor antagonist, Anakinra). In this study, lung transplant participants who are randomized to the treatment group will have the study drug injected into the solution that their donor lungs are kept in prior to transplant.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2026-02-01
Completion Date
2027-12
Last Updated
2026-02-13
Healthy Volunteers
No
Conditions
Interventions
Anakinra
100 mg injection
Locations (1)
Northwestern University
Chicago, Illinois, United States