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NOT YET RECRUITING
NCT07410312
EARLY_PHASE1

BRIDGE - Blocking Receptor of IL-1β for Donor Graft Edema Reduction

Sponsor: Northwestern University

View on ClinicalTrials.gov

Summary

This study will determine if primary graft dysfunction (which causes low blood oxygen levels and fluid or inflammation in the lungs) after lung transplant can be prevented through the use of the study drug (IL-1 receptor antagonist, Anakinra). In this study, lung transplant participants who are randomized to the treatment group will have the study drug injected into the solution that their donor lungs are kept in prior to transplant.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

20

Start Date

2026-02-01

Completion Date

2027-12

Last Updated

2026-02-13

Healthy Volunteers

No

Interventions

DRUG

Anakinra

100 mg injection

Locations (1)

Northwestern University

Chicago, Illinois, United States