Clinical Research Directory

Screening Criteria: * Subjects must be at least 19 years of age at the time of screening. * Subjects must be admitted to the intensive care unit (ICU). * Subjects must be receiving vasopressor therapy for shock. * Subjects must have a documented history of maximum vasopressor requirement with a vasopressor-inotropic score (VIS) of 12 or greater, calculated as follows: VIS = dopamine dose (µg/kg/min) + dobutamine dose (µg/kg/min) + 10 × milrinone dose (µg/kg/min) + 100 × epinephrine dose (µg/kg/min) + 100 × norepinephrine dose (µg/kg/min) + 10,000 × vasopressin dose (U/kg/min) Inclusion Criteria: * Subjects must meet all screening criteria. * Subjects must have central venous access suitable for the administration of parenteral nutrition (PN). * Subjects must demonstrate a decreasing vasopressor requirement, defined as a current VIS of 12 or less at the time of enrollment. Exclusion Criteria: * Subjects with contraindications to enteral nutrition (EN) or parenteral nutrition (PN) at the time of enrollment will be excluded. * Subjects requiring specific nutritional management, including but not limited to long-term home enteral nutrition, long-term parenteral nutrition, or a diagnosis of refeeding syndrome, will be excluded. * Subjects who are pregnant or breastfeeding will be excluded. * Subjects with severe comorbid conditions associated with an estimated life expectancy of less than three months will be excluded. * Subjects with a documented do-not-resuscitate (DNR) order will be excluded. * Subjects with active gastrointestinal bleeding will be excluded. * Subjects who have undergone gastrointestinal surgery within one month prior to enrollment will be excluded. * Subjects currently participating in another randomized controlled trial comparing enteral nutrition and parenteral nutrition will be excluded.