Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
NOT YET RECRUITING
NCT07411560
PHASE1

A Study Looking at How Weekly Injections of Two Hormones - GIP and Amylin - Affect Stomach-related Side Effects in People Who Are Overweight or Obese

Sponsor: Novo Nordisk A/S

View on ClinicalTrials.gov

Summary

This trial is being done to look at the safety and effect of combining cagrilintide and NNC0480-0389 in people living with overweight and obesity compared to taking cagrilintide alone. In one period participants will get two medicines: cagrilintide and NNC0480-0389. In the other period, participants will get cagrilintide together with a placebo version of NNC0480-0389.The placebo looks like the real treatment but does not have any active medicine in it. Cagrilintide and NNC0480-0389 is a new medicine being tested to help people with type 2 diabetes and/or overweight or obesity. The trial medicines is not yet approved for use outside of clinical trials. Participants will receive the trial medicines the way the trial doctor has described. The study will last for about 4.5 months.

Official title: Single-centre Study Investigating the Role of Long-acting Subcutaneous Glucose-dependent Insulinotropic Polypeptide Receptor Agonist (GIP RA) in Combination With Long-acting Subcutaneous Amylin Receptor Agonist on Gastrointestinal Tolerability in Participants With Overweight or Obesity

Key Details

Gender

FEMALE

Age Range

18 Years - 64 Years

Study Type

INTERVENTIONAL

Enrollment

100

Start Date

2026-02-09

Completion Date

2027-01-26

Last Updated

2026-02-17

Healthy Volunteers

No

Conditions

Interventions

DRUG

Glucose-dependent Insulinotropic Polypeptide (GIP)

Participants will receive GIP subcutaneously.

DRUG

Cagrilintide

Participants will receive Cagrilintide subcutaneously.

DRUG

Placebo GIP

Participants will receive placebo matched to GIP subcutaneously.

Locations (1)

Parexel Research Unit

Harrow, Middlesex, United Kingdom